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Jonathan T C Kwan
 
 
MB MS Dipl Imm MSc MD MBA
 
 
FRCPI FRCPE FRCP
 
 
Certificate of Teaching
 
     
 
Medical Director
 
 
Director of Infection Prevention & Control
 
 
Consultant Physician & Nephrologist
 
 
Epsom & St Helier University Hospitals NHS Trust
 
 
St Helier Hospital
 
 
Carshalton, Surrey SM5 1AA
 
 
England
 
 
 
 
Honorary Senior Lecturer in Medicine
 
 
St George's Hospital Medical School
 
 
University of London
 
 
Tooting, London
 
 
England
 
 
CAREER
 
 

Graduated at King’s College Hospital Medical School. Received junior medical training in King’s, St Helier, St George’s and Royal London Hospitals. Carried out research in renal bone disease and carbamylated haemoglobin in uraemia. Formerly Lecturer in Medicine at the Royal London Medical College. Appointed as a Consultant at St Helier in 1994.

 
 
LEADERSHIP
 
 
  • Medical Director, Epsom & St Helier University Hospitals NHS Trust from 2008
  • Director of Infection Prevention & Control from 2008
  • Member of the Epsom & St Helier University Hospital NHS Trust Board
  • Ex-Clinical Director of Renal Services 2001 - 2008
  • Consultant Member of General & Emergency Medicine Directorate
  • Consultant Member of Renal & Cancer Directorate
  • Member of St George’s/St Helier Education Co-coordinating Committee
  • Member of the Kent Surrey Sussex Renal Modernisation Committee
  • Member of the S W London Renal Service Planning Group
  • Member of S W London and Surrey Renal Network Board
  • Honorary President of SHAK, St Helier Association of Kidney Patients
  • Trustee of South West Thames Kidney Fund
  • Co-chairman of Renal Inpatient Service Development Group
  • Ex-Member of the London NHS Renal Modernisation Committee
  • Ex-Nationally elected Executive Member of United Kingdom Renal Association
  • Ex-Elected Member of the Clinical Affairs Board of the Renal Association
  • Ex-Elected Member of the Research Committee of the Renal Association
  • Ex-Lead for London, Renal Association Service Provision and Delivery Subcommittee
 
 
SERVICE GROWTH & IMPROVEMENT
 
 
  • Fifteen years ago, we had 14 inpatient beds, 16 in-centre dialysis stations, 4 outreach sites and no satellite dialysis unit. We now have 60 inpatient beds, 34 in-centre dialysis stations, 14 outreach clinic sites and 5 satellite dialysis units.
 
 
CLINICAL EXCELLENCE
 
 
  • Finalist of "Hospital Doctor of the Year" in the Renal Team Category 2007
  • Winner of "Hospital Doctor of the Year" in 'Innovation Team Award' 2004
  • Achieved "Investor in People" status for the Renal Unit 2004
  • Named as the Best Unit in Patient Education by S W London SHA 2004
  • Award of Merit in NHS Champions, nimination run by King's Fund and London Evening Standard 2004
  • St helier was names as the Transplant Unit with the Best Clinical Outcome in the Country by Dr Foster's Hospital Guide 2003
  • Led the Renal Team Commission of Health Improvement Review May 2001 - received an excellent CHI report related to the Renal Services
 
 
RESEARCH
 
 
I am a Trustee and Director Member of the South West Thames Kidney Fund which manages the South West Thames Institute for Renal Research. I am heavily involved in the running of the Institute as well as ongoing fund raising to maintain the financial solvency of the Institute. Renal Research contributes a quarter of all Trust research output annually. Renal Research at St Helier has been given a “Strong” rating by the NHS R & D Research Assessment Exercise.
 
 
UNDERGRADUATE AND POSTGRADUATION TEACHING AND TRAINING
 
 
Undergraduate Medical Students
 
 
  • Programme Director of the Kidney & Body Fluid Module for the 5 year undergraduate Course at St George's Hospital Medical School
  • Voted the “Best Clinical Teacher” 2001 by the St George’s Medical School Student Club
 
 
House Officer and SHO Training
 
 
  • Royal College of Physicians College Tutor at St Helier since 2002 – co-coordinating protected clinical teaching for SHO and PRHO. Maintaining RCP approval of the junior doctor posts by ensuring the educational content of the posts meeting the RCP requirement.
 
 
Specialist Registrar Teaching and Training
 
 
  • Royal College of Physician Renal Regional Specialty Advisor (RSA) for the South Thames (West) Region. 1997 - 2004
  • Member of Specialty Training Committee (STC) in Nephrology in South Thames 1997 - 2004
  • Member of Specialty Training Committee (STC) in General Internal Medicine (GIM) in South Thames 1997 - 2003
  • Active Faculty Member of Brighton University MSc course in Renal Medicine
 
 
Teaching and Training at large
 
 
  • Member of the Programme Planning Committee of “Nephrology in Practice” of the annual British Renal Symposium 1997 - 2001
  • Faculty member of the National Peritoneal Dialysis Academy since 2000. Twice yearly teaching sessions for SpR and Consultants
  • Frequently lecturing GP groups in both National and Regional Teach-In Days
  • Co-organised 3 National Symposiums on Renal Topics with a national audience:
    Ethnicity and Renal Failure – Disparity or Diversity 2003
    Early Management of Renal Disease in Primary Care-Prevention or Prevarication 2004
    Patient Choice and Renal NSF – Options or Opinions 2005
 
 
PUBLICATIONS
 
 
1
Primary cerebral lymphoma mimicking tuberculosis: case report.
Barker P R, Kwan J T C, Patten J P.
Neurology Neurosurgery & Psychiatry 1987, 50: 358-360.
 
 
 
 
2
Therapeutic range of cyclosporin in renal transplant patients by specific monoclonal radioimmunoassay.
Kwan J T C, Foxall P J D, Townend J N, Thick M G, Bending M R, Eisinger A J.
Lancet 1987; 2: 962-963.
 
 
 
 
3
Does nifedipine ameliorate cyclosporin A nephrotoxicity? [letter].
Kwan J T C, Foxall P J D, Townend J N, Bending M R, Eisinger A J.
British Medical Journal 1987; 295: 851.
 
 
 
 
4
Interaction of cyclosporin and itraconazole [letter].
Kwan J T C, Foxall P J, Davidson D G, Bending M R, Eisinger A J.
Lancet 1987; 2: 282.
 
 
 
 
5
Synovial amyloid in a chronic haemodialysis patient containing ß-2 microglobulin.
Bruckner F E, Burke M, Pereira R S, Eisinger A J, Bending M R,
Kwan J T C, Osman A K, Watson B.
Annals of Rheumatic Diseases 1987; 46: 634-637.
 
 
 
 
6
Caecal perforation in a renal transplant patient with disseminated histoplasmosis.
Brett M T, Kwan J T C, Bending M R.
Journal of Clinical Pathology 1988; 41: 992-5.
 
 
 
 
7
Isolation of organisms in CAPD peritonitis: use of nutrient broth cultures and Bactec blood culture media.
Stokely D J, Kwan J T C, Bending M R, Chin A T, Eisinger A J.
Journal of Hospital Infection 1988; 11: 77-81.
 
 
 
 
8
Determination of carbamylated hemoglobin by high-performance liquid chromatography.
Kwan J T C, Carr E C, Bending M R, Barron J L.
Clinical Chemistry 1990; 36: 607-610.
 
 
 
 
9
Comment on "Use of aminohydroxypropylidene bisphosphonate (AHPrBP, "APD") for the treatment of hypercalcemia in patients with renal impairment" by Yap et al [letter].
Kwan J T C, Cunningham J.
Clinical Nephrology 1991; 35/4: 182.
 
 
 
 
10
Monitoring of renal transplant graft function by regular postal capillary blood sampling.
Kwan J T C, Foxall P J, Bending M R.
Annals of Clinical Biochemistry 1991; 28: 303-304.
 
 
 
 
11
Carbamylated haemoglobin, urea kinetic modelling and adequacy of dialysis in haemodialysis patients.
Kwan J T C, Carr E C, Neal A D, Burdon J, Raftery M J, Marsh F P, Barron J L, Bending M R.
Nephrology Dialysis Transplantation 1991; 6: 38-43.
 
 
 
 
12
Mycobacterial infection is an important infective complication in British Asian dialysis patients.
Kwan J T C, Hart P D, Raftery M J, Cunningham J, Marsh F P.
Journal of Hospital Infection 1991; 19: 249-255.
 
 
 
 
13
Relative sensitivity of serum and urinary retinol binding protein and alpha-1 microglobulin in the assessment of renal function.
Ayatse J O I, Kwan J T C. Annals of Clinical Biochemistry 1991; 28: 514-516.
 
 
 
 
14
Crescentic transformation in primary membranous glomerulonephritis.
Kwan J T C, Moore R H, Dodd S M, Cunningham J.
Postgraduate Medical Journal 1991; 67: 574-576.
 
 
 
 
15
Changes in total body bone mineral content and regional bone mineral density in renal patients following renal transplantation.
Kwan J T C, Almond M K, Evans K, Cunningham J.
Mineral and Electrolyte Metabolism 1992; 18: 166-168.
 
 
 
 
16
'Pulse' oral calcitriol in uraemic patients: rapid modification of parathyroid response to calcium.
Kwan J T C, Almond M K, Beer J C, Noonan K, Evans S J, Cunningham J.
Nephrology Dialysis Transplantation 1992; 7: 829-34.
 
 
 
 
17
Carbamylated haemoglobin in normal, diabetic and uraemic patients.
Kwan J T C, Carr E C, Barron J L, Bending M R.
Annals of Clinical Biochemistry 1992; 29: 206-209.
 
 
 
 
18
EBV-genome positive monoclonal B cell cerebral lymphoma in a renal allograft recipient following OKT3 therapy.
Kwan J T C, Cotter FE, Pollock LE, Altmann P, Lord RH, Raftery MJ, Cunningham J.
Nephrology Dialysis Transplantation 1992; 7: 360-361.
 
 
 
 
19
Juvenile chronic arthritis and Wegener's granulomatosis.
Wedderburn L R, Kwan J T C, Thompson P W, Rudge S R.
British Journal of Rheumatololgy 1992; 31: 121-123.
 
 
 
 
20
Renal transplantation across positive historical crossmatches.
Navarrete C, Kwan J T C, McCloskey D, Brown J, Limones M, Raftery MJ, Lord RHH.
In: Touraine J L, Traeger J, Bétuel H, Dubernard J M, Revillard J P, Dupuy C,eds.
Transplantation and Clinical Immunology, Evaluation and Monitoring in Transplantation, Proceedings of Twenty-Fourth International Conference, Lyon. Excerpta Medica:75-79, 1992.
 
 
 
 
21
Carbamylated haemoglobin - a retrospective index of time-averaged urea concentration.
Kwan J T C, Carr EC, Barron J L, Bending M R.
Nephrology Dialysis Transplantation 1993; 8: 565-567.
 
 
 
 
22
HLA antigen frequencies in renal transplant recipients and non-immunosuppressed patients with non-melanoma skin cancer.
Glover MT, Bodmer J, Bodmer W, Kennedy L J, Brown J, Navarrete C,
Kwan J T C, Leigh I M. European Journal of Cancer 1993; 29A/4: 520-524.
 
 
 
 
23
Successful treatment of concomitant pulmonary nocardiosis and aspergillosis in an immunocompromised renal patient.
Holt R I G, Kwan J T C, Sefton A M, Cunningham J.
European Journal of Clinical Microbiology & Infectious Diseases 1993; 12: 110-112.
 
 
 
 
24
Femoral neuropathy in renal transplantation.
Junaid I, Kwan J T C, Lord R H H.
Transplantation 1993; 56/1: 240-241.
 
 
 
 
25
Serum and urinary alpha-1 microglobulin levels in renal disease.
Ayatse J O, Kwan J T C.
East African Medical Journal 1993; 70/12:789-92.
 
 
 
 
26
Parathyroid sensing of the direction of change of calcium in uremia.
Kwan J T C, Beer J C, Noonan K, Cunningham J.
Kidney International 1993; 43: 1104-1109.
 
 
 
 
27
Loss of regional bone mineral density in the first 12 months following renal transplantation.
Almond M K, Kwan J T C, Evans K, Cunningham J.
Nephron 1994; 66:52-57.
 
 
 
 
28
Acyclovir neurotoxicity following oral therapy: prevention and treatment in patients on haemodialysis.
Beales P, Almond M K, Kwan J T C.
Nephron 1994; 66:362-363.
 
 
 
 
29
Non-melanoma skin cancer in renal transplant recipients: the extent of the problem and a strategy for management.
Glover M T, Niranjan N , Kwan J T C, Leigh I M.
British Journal of Plastic Surgery 1994; 47:86-89.
 
 
 
 
30
Increased prevalence of hairy leukoplakia, leukoplakia, erythrematous candidiasis and gingival hyperplasia in renal transplant recipients.
King G N, Healy C M, Glover M T, Kwan J T C, Williams DM, Leigh IM, Thornhill MH.
Oral Surgery, Oral Medicine, Oral Pathology 1994; 78:718-26.
 
 
 
 
31
Increased prevalence of dysplastic and malignant lip lesions in renal transplant recipients.
King G N, Healey C M, Glover M T, Kwan J T C, Williams DM, Leigh IM, Thornhill MH.
New England Journal of Medicine 1995; 332:1052-57.
 
 
 
 
32
Reversible renal failure due to the antiphospholipid syndrome, pre-eclampsia and renal thrombotic microangiopathy.
Kon S P, Kwan J T C, Raftery M J.
Clinical Nephrology 1995;44/4:271-273.
 
 
 
 
33
Bilateral nephrocalcinosis.
Kwan J T C, Marsh F P.
New England Journal of Medicine 1996;334/17:1105.
 
 
 
 
34
Membranous nephropathy complicating adenolymphoma of the parotid (Warthin's tumour)?
Kon S P, Fan S, Kwan J T C, Dodd S, Raftery M J.
Nephron 1996;73:692-694.
 
 
 
 
35
Successful outcome of treating haemolytic uraemic syndrome associated with cancer chemotherapy with immunoadsorption.
D’Souza R J D, Kwan J T C, Hendry B M, Fallon M, Cunningham D.
Clinical Nephrology 1997; 47:58-59.
 
 
 
 
36
Icodextrin hypersensitivity in a CAPD patient.
M K L Lam-Po-Tang, Bending M R, Kwan J T C.
Peritoneal Dialysis International 1997;17:82-84.
 
 
 
 
37
Delayed detection of peritonitis by patients receiving home automated peritoneal dialysis.
Steele M, Kwan J T C.
Peritoneal Dialysis International 1997;17(6):617.
 
 
 
 
38
Renal Replacement Therapy for the Elderly.
Kwan J T C.
Geriatric Medicine CME Bulletin 1998; 1(3):68-70.
 
 
 
 
39
Monocyte expression of tissue factor and adhesion molecules: the link with accelerated coronary artery disease in patients with chronic renal failure.
Al-Saady N M, Leatham E W, Gupta S, Kwan J T C, Eastwood J B, Seymour C A.
Heart 1999; 81(2):134-140.
 
 
 
 
40
OKT3 in renal allografts: survival and complications.
D’Souza R J D, Kwan J T C, Chang R, Bending M R.
Clinical Nephrology 1999; 51(4):257-258.
 
 
 
 
41
Calcaneal bone ultrasonometry in patients with renal failure treated with dialysis.
Patel S, Kwan J T C, McGee G, Thomas G, Johnson D.
Clinical Nephrology 1999; 51(6):387-388.
 
 
 
 
42
Is there a role for adjuvant therapy in patients being treated with epoetin?
Horl W H, Brox A G, Cavill I, Dratwa M. Drueke T B, Gokal R, Kwan J T C, Mehls O, Sunder-Plassmann G, Tielemans C, Tarng D-C, Warner C.
Nephrology Dialysis Transplantation 1999; 14(Suppl 2):50-60.
 
 
 
 
43
The use of optical sensors to understand cellular interactions with renal cells.
Newman D J, Thakkar H, Lam-Po-Tang M K, Kwan J T C.
Renal Failure 1999; 21: 349-357.
 
 
 
 
44
Post-transplant lymphoproliferative disorder: an unusual presentation in a patient receiving tacrolimus.
Gallagher H, Kwan J T C, Andrews P A.
Nephrology Dialysis Transplantation 2000; 15:928-930.
 
 
 
 
45
Acute Renal Failure in elderly people.
Kwan J T C.
Geriatric Medicine CME Bulletin 2000; 2(2):53-55.
 
 
 
 
46
The treatment of normotensive diabetics.
Kwan J T C.
Postgraduate Doctor 2000; 16(suppl): 1-6.
 
 
 
 
47
Successful transplantation of kidneys with focal segmental glomerulosclerosis.
Rea R, Smith C, Sandhu K, Kwan J T C, Tomson C.
Nephrology Dialysis Transplantation 2001; 16: 416-417.
 
 
 
 
48
NephroQuiz- Acute Renal Failure and Hypercalcaemia
Gunda S S, Kwan J T C, Sampson S.
Nephrology Dialysis Transplantation 2001; 16: 425-426.
 
 
 
 
49
Bordetella holmesii Bacteraemia in an individual on haemodialysis.
Greig J R, Gunda S S, Kwan J T C.
Scandinavian Journal of Infectious Disease 2001; 33: 716-717.
 
 
 
 
50
European randomised trial of dual versus triple tacrolimus-based regimens for control of acute rejection in renal allograft recipients.
Chang R W S, Snowden S, Palmer A, Kwan J T C, Nicholson M, Kashi S H, Fernando O N, Perner F,
Nield G H.
Transplantation International 2001; 14:384-390.
 
 
 
 
51
Bordetella holmesii Bacteraemia in an individual on Haemodialysis.
Greig J R, Gunda S S, Kwan J T C.
Scand J Infect Dis 2001; 33:716-717.
 
 
 
 
52
Prevalence and causes of low bone density and fractures in kidney transplant patients
Patel S, Kwan J T C, McCloskey E, McGee G, Thomas G, Johnson D, Wills R, Ogunremi L, Barron J.
Journal of Bone Mineral Research 2002; 16(10):1863-70.
 
 
 
 
53
Pulmonary renal syndrome: a four year single-centre experience.
Gallagher H, Kwan J T C, Jayne R W.
American Journal of Nephrology 2002; 39(1):42-47.
 
 
 
 
54
The management of normotensive diabetics.
Kwan J T C.
Postgraduate Doctor 2002; 24: 70-73.
 
 
 
 
55
Effect of control of thermal balance on vascular stability in hemodialysis patients: Result of a European Randomised Clinical Trial.
Maggiore Q, Pizzarelli F, Santoro A, Panzetta G, Bonforte G, Hannedouche T, Alavarez de Lara M A, Tsouras D, Loureiro A, Ponce P, sulova S, Van Roost G, Brink H, Kwan J T C.
American Journal of Kidney Diseases 2002; 40(2):280-290.
 
 
 
 
56
Peritonitis due to dematiaceous mould exophiala dermatitidis complicating continuous ambulatory peritoneal dialysis and review of the literature.
Greig J R, Harkness M, Taylor P, Hashmi C, Liang S, Kwan J TC.
Clinical Microbiology & Infection 2003; 9(7):713-715.
 
 
 
 
57
Metastatic eccrine porocarcinoma presenting with lymphoedema.
Ameen M, Kwan J, Mortimer PS.
Br J Dermatol. 2004 Mar;150(3):607-9.
 
 
 
 
58
Development of an outpatient finger-prick glomerular filtration rate procedure suitable for epidemiological studies. Niculescu-Duvaz, D'Mello L, Maan Z, Barron JL, Newman DJ, Dockrell MEC, Kwan JTC.
 
 
Kidney International 2006; ; 69(7):1272-5.
 
 
 
 
59
Successful treatment of Cresentic Transformation of Membraneous glomerulonephritis with immunosuppression.
Hall A, Sampson S, Kwan J T C.
 
 
Nephrology Dialysis Transplantation 2006; 21(4):1136-7.
 
 
 
 
60

Is early treatment of anaemia with epoetin-alpha beneficial to pre-dialysis chronic kidney disease patients? Results of a multicentre, open-label, prospective, randomized, comparative group trial.

 
 
Macdougall I C, Temple R M, Kwan J T C.
 
 
Nephrology Dialysis Transplantation 2007;22(3):784-93.
 
 
 
 
61

Epoetin delta, erythropoietin produced in a human cell line, in the management of anaemia in predialysis chronic kidney disease patients Kwan J T C , Pratt R D. The Epoetin Delta Study Group. Current Medical Research & Opinion 2007;23(2):307-11. .

 
 
 
 
 
 
62
BMP-7 and Proximal Tubule Epithelial Cells: Activation of Multiple Signaling Pathways Reveals a Novel Anti-fibrotic Mechanism.
 
 
Motazed R, Colville-Nash P, Kwan J T C, Dockrell M E C.
 
 
Pharmaceutical Research 2008; 25(10):2440-6.
 
 
 
 
63
Long-term efficacy and safety profile of lanthanum carbonate: results for up to 6 years of treatment. SPD405-309 Lanthanum Study Group Hutchison A J, Barnett M E, Krause R, Kwan J T C, Siami GA.
 
 
Nephron 2008;110(1):c15-23.
 
 
 
 
64
Healthcare resource utilization for anemia management: current practice with erythropoiesis-stimulating agents and the impact of converting to once-monthly C.E.R.A.
 
 
Saueressig U. Kwan J T C. De Cock E. Sapede C.
 
 
Blood Purification. 2008;26(6):537-46.
 
       
  65 Albumin induces interleukin-6 release from primary human proximal tubule epithelial cells  
   
Pearson A L, Colville-Nash P, Kwan J R, Dockrell M E
 
   
J Nephrol. 2008 Nov-Dec;21(6):887-93.
 
       
 
66

Anaemia management with subcutaneous epoetin delta in patients with chronic kidney disease (predialysis, haemodialysis, peritoneal dialysis): results of an open-label, 1-year study.

 
 
Frei U, Kwan J T C, Spinowitz B S, and Epoetin Delta 3002 Study Group.
 
 
BioMed Central Nephrology 2009, 10:5
 
 
 
 
TEXTBOOK
 
 
  1. "Renal Support of the Critically Ill" in "Textbook of Intensive Care", eds Withington & Goldhill, 1997 by Chapman & Hall.
    Kwan J T C.
 
 
 
 

Occasional Editorial Work for the following journals
Heart
Nephron
Clinical Nephrology
Kidney International
British Medical Journal
Bone Marrow Transplantation
American Journal of Nephrology
Nephrology Dialysis Transplantation
Journal of American Society of Nephrology

 
 
Referee activities for the following organisations in the last year
NHS Higher Technology Assessment (HTA) Programme
NHS Northern Region R & D Committee
NICE Report for Cinacalcet Use